🕓 Last Updated on: October 2, 2026

Fundamentals of Nursing Practice Test #2: Infection Control & Asepsis

This free Fundamentals of Nursing Practice Test #2 covers infection control and asepsis — isolation precautions, PPE, sterile technique, hand hygiene, and sharps safety. Work through 10 timed questions, then check every answer with the full rationales below. No sign-up required.

Loading quiz…

All 10 Questions With Answers & Rationales

Prefer to work at your own pace? Every question from the timed quiz above is listed here in full. Choose your answer, then tap Show Answer & Rationale to check it.

Question 1: Isolation

A client is admitted with suspected pulmonary tuberculosis. Which precautions should the nurse use?

  • A. An N95 respirator and a negative-pressure room
  • B. A surgical mask only
  • C. Gown and gloves only
  • D. Standard precautions only
Show Answer & Rationale

Answer: A. An N95 respirator and a negative-pressure room

Rationale: Tuberculosis spreads by airborne droplet nuclei that stay suspended in the air. Airborne precautions require a fit-tested N95 (or higher) respirator and an airborne infection isolation room with negative pressure. A surgical mask does not filter these particles; the client wears a surgical mask when leaving the room.

Question 2: Sterile Technique

Which action by the nurse contaminates a sterile field?

  • A. Reaching across the sterile field
  • B. Keeping sterile items above waist level
  • C. Treating the 1-inch border as non-sterile
  • D. Facing the sterile field at all times
Show Answer & Rationale

Answer: A. Reaching across the sterile field

Rationale: Reaching across the field can drop particles or brush the field with a non-sterile arm or sleeve. Keeping items above the waist, facing the field, and treating the outer 1-inch border as contaminated are all correct sterile technique.

Question 3: Isolation

Which type of transmission-based precautions does a client with influenza require?

  • A. Airborne precautions
  • B. Droplet precautions
  • C. Contact precautions only
  • D. Protective (neutropenic) precautions
Show Answer & Rationale

Answer: B. Droplet precautions

Rationale: Influenza spreads by large respiratory droplets that travel a short distance. Droplet precautions — a surgical mask on entering the room, plus standard precautions — are used. Airborne precautions are for diseases like tuberculosis, measles, and varicella.

Question 4: Sharps Safety

After giving an injection, what should the nurse do with the needle?

  • A. Recap it using both hands
  • B. Bend the needle before discarding it
  • C. Activate the safety device and place it in the sharps container
  • D. Leave it on the tray to discard later
Show Answer & Rationale

Answer: C. Activate the safety device and place it in the sharps container

Rationale: Activating the safety device and discarding the needle immediately in a puncture-resistant sharps container prevents needlestick injuries. Two-handed recapping and bending needles are leading causes of needlesticks, and leaving a used needle on a tray puts the next person at risk.

Question 5: Chain of Infection

Hand hygiene breaks which link in the chain of infection?

  • A. Infectious agent
  • B. Reservoir
  • C. Susceptible host
  • D. Mode of transmission
Show Answer & Rationale

Answer: D. Mode of transmission

Rationale: Hands are the most common way microorganisms move from one person or surface to another. Cleaning them interrupts the mode of transmission. Vaccination strengthens the susceptible host, and treating the infection targets the agent.

Question 6: Sterile Gloves

When putting on the second sterile glove, how should the nurse handle it?

  • A. Grasp the inside of the cuff with the gloved hand
  • B. Pull it on by touching the inner skin side
  • C. Adjust it with the bare hand once it is on
  • D. Slide the gloved fingers under the folded cuff of the second glove
Show Answer & Rationale

Answer: D. Slide the gloved fingers under the folded cuff of the second glove

Rationale: A sterile glove may only touch another sterile surface. The outside of the second glove, under the cuff, is sterile, so the gloved fingers slide underneath it. The inside of the glove is touched only by the bare hand, and only while putting on the first glove.

Question 7: Prevention

What is the single most effective way for nurses to prevent healthcare-associated infections?

  • A. Giving prophylactic antibiotics to all clients
  • B. Performing hand hygiene
  • C. Wearing gloves for every client contact
  • D. Placing every client in isolation
Show Answer & Rationale

Answer: B. Performing hand hygiene

Rationale: Hand hygiene remains the most effective measure for preventing healthcare-associated infections. Gloves do not replace it, routine antibiotics promote resistance, and isolating every client is neither practical nor necessary.

Question 8: Protective Precautions

A client with neutropenia is on protective precautions. Which action is appropriate?

  • A. Allow fresh flowers in the room
  • B. Take temperatures rectally
  • C. Screen visitors and staff for signs of illness before they enter
  • D. Share equipment with the roommate
Show Answer & Rationale

Answer: C. Screen visitors and staff for signs of illness before they enter

Rationale: A client with a very low neutrophil count cannot fight infection, so anyone who is ill is kept out. Fresh flowers and standing water can harbor organisms, rectal temperatures can injure the mucosa and introduce bacteria, and equipment should be dedicated to the client.

Question 9: Hand Hygiene

When using an alcohol-based hand rub, what should the nurse do?

  • A. Rinse the hands with water afterward
  • B. Dry the hands with a paper towel
  • C. Apply it to the palms only
  • D. Rub all surfaces of the hands until they are dry
Show Answer & Rationale

Answer: D. Rub all surfaces of the hands until they are dry

Rationale: Alcohol needs contact time to kill organisms, so the rub should cover all surfaces of the hands and fingers and be rubbed in until dry, about 20 seconds. Rinsing or towel-drying removes it before it has worked.

Question 10: PPE

When putting on personal protective equipment, which item does the nurse put on first?

  • A. Gloves
  • B. Goggles
  • C. Gown
  • D. Face shield
Show Answer & Rationale

Answer: C. Gown

Rationale: The CDC sequence for putting on PPE is gown, then mask or respirator, then goggles or face shield, then gloves. Gloves go on last so they can be pulled over the cuffs of the gown.

Next: Test #3 — Vital Signs & Assessment →
Free NCLEX Prep

Fundamentals of Nursing Practice Tests

Six free, timed tests on the nursing basics — every question with a full rationale. Work through all six to build speed and confidence.

6
Timed Tests
60
Questions
100%
Free

More free practice tests

+

Dosage Calculations

Six timed tests: tablets, liquids, IV flow rates, pediatric, heparin and insulin.

→
+

Pharmacology

NCLEX pharmacology practice tests with rationales.

→
+

Health Promotion and Maintenance

50 NCLEX-style questions with rationales.

→

NurseStudyPrep.com

Want more than 60?

1,800 NCLEX-style questions with a written rationale on every option, plus progress tracking by topic.

Try it free for 2 days
Photo of author

Anna Curran. RN, BSN, PHN

Anna Curran, RN, BSN, PHN is a Critical Care ER nurse with over 30 years of bedside experience. She has taught BSN and LVN students and began writing study guides to strengthen their knowledge, especially for NCLEX success. Anna founded Nursestudy.net to share evidence‑based nursing diagnoses, care plans, and clinical review materials that support safe, up‑to‑date nursing practice.