How to setup and IV and IV Piggyback – Skills March 29, 2022December 2, 2014 by Anna Curran. RN, BSN, PHNLast updated on March 29th, 2022 at 09:08 am/p/////>When given intravenously, a drug is delivered immediately to the bloodstream and tends to take effect more quickly than when given by any other route. Consequently, health care practitioners closely monitor people who receive an intravenous injection for signs that the drug is working or is causing undesired side effects. Also, the effect of a drug given by this route tends to last for a shorter time. Therefore, some drugs must be given by continuous infusion to keep their effect constant./